Formin Cdc12's specific actin assembly properties are tailored for cytokinesis in fission yeast.

ABSTRACT: Formins generate unbranched actin filaments by a conserved, processive actin assembly mechanism. Most organisms express multiple formin isoforms that mediate distinct cellular processes and facilitate actin filament polymerization by significantly different rates, but how these actin assembly differences correlate to cellular activity is unclear. We used a computational model of fission yeast cytokinetic ring assembly to test the hypothesis that particular actin assembly properties help tailor formins for specific cellular roles. Simulations run in different actin filament nucleation and elongation conditions revealed that variations in formin's nucleation efficiency critically impact both the probability and timing of contractile ring formation. To probe the physiological importance of nu

SUBMITTER: Homa KE 

PROVIDER: S-EPMC8390969 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature