Biophysical properties of corneal cells reflect high myopia progression.

ABSTRACT: Myopia is a common ocular disorder with significant alterations in the anterior ocular structure, including the cornea. The cell biophysical phenotype has been proposed to reflect the state of various diseases. However, the biophysical properties of corneal cells have not been characterized during myopia progression and their relationship with myopia remains unknown. This study characterizes the biophysical properties of corneal cells in normal, myopic, and recovered conditions, using two classical myopia models. Surprisingly, myopic corneal cells considerably reduce F-actin and microtubule content and cellular stiffness and generate elevated traction force compared with control cells. When myopia is restored to the healthy state, these biophysical properties are partially or fully restore

SUBMITTER: Xin Y 

PROVIDER: S-EPMC8391025 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature