Mask R-CNN Based C. Elegans Detection with a DIY Microscope.

ABSTRACT: Caenorhabditis elegans (C. elegans) is an important model organism for studying molecular genetics, developmental biology, neuroscience, and cell biology. Advantages of the model organism include its rapid development and aging, easy cultivation, and genetic tractability. C. elegans has been proven to be a well-suited model to study toxicity with identified toxic compounds closely matching those observed in mammals. For phenotypic screening, especially the worm number and the locomotion are of central importance. Traditional methods such as human counting or analyzing high-resolution microscope images are time-consuming and rather low throughput. The article explores the feasibility of low-cost, low-resolution do-it-yourself microscopes for image acquisition and automated evaluation by dee

SUBMITTER: Fudickar S 

PROVIDER: S-EPMC8391161 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature