Genetic Variations Associated with Long-Term Treatment Response in Bipolar Depression.

ABSTRACT: Several pharmacogenetic-based decision support tools for psychoactive medication selection are available. However, the scientific evidence of the gene-drug pairs analyzed is mainly based on pharmacogenetic studies in patients with major depression or schizophrenia, and their clinical utility is mostly assessed in major depression. This study aimed at evaluating the impact of individual genes, with pharmacogenetic relevance in other psychiatric conditions, in the response to treatment in bipolar depression. Seventy-six patients diagnosed with bipolar disorder and an index major depressive episode were included in an observational retrospective study. Sociodemographic and clinical data were collected, and all patients were genotyped using a commercial multigene pharmacogenomic-based tool (Ne

SUBMITTER: Anmella G 

PROVIDER: S-EPMC8391230 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature