Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis.

ABSTRACT: Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments. However, due to shared cellular markers with several other phenotypes, the specific targeting of myofibroblasts has long presented a scientific and clinical challenge. In recent years, myofibroblasts have drawn much attention among scientific research communities from multiple disciplines and specialisations. As further research uncovers the characterisations of myofibroblast formation, function, and regulation, the realisation of novel interventional routes for myofibroblas

SUBMITTER: Tai Y 

PROVIDER: S-EPMC8391320 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature