Ontology highlight
ABSTRACT:
SUBMITTER: Herrmann HA
PROVIDER: S-EPMC8391396 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Herrmann Helena A HA Rusz Mate M Baier Dina D Jakupec Michael A MA Keppler Bernhard K BK Berger Walter W Koellensperger Gunda G Zanghellini Jürgen J
Cancers 20210817 16
<h4>Background</h4>Mass spectrometry-based metabolomics approaches provide an immense opportunity to enhance our understanding of the mechanisms that underpin the cellular reprogramming of cancers. Accurate comparative metabolic profiling of heterogeneous conditions, however, is still a challenge.<h4>Methods</h4>Measuring both intracellular and extracellular metabolite concentrations, we constrain four instances of a thermodynamic genome-scale metabolic model of the HCT116 colorectal carcinoma c ...[more]