ZNF768 Expression Associates with High Proliferative Clinicopathological Features in Lung Adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) is the most common type of lung cancer and a leading cause of cancer-related deaths worldwide. Despite important recent advances, the prognosis for LUAD patients is still unfavourable, with a 5 year-survival rate close to 15%. Improving the characterization of lung tumors is important to develop alternative options for the diagnosis and the treatment of this disease. Zinc-finger protein 768 (ZNF768) is a transcription factor that was recently shown to promote proliferation and repress senescence downstream of growth factor signaling. Although ZNF768 protein levels were found to be elevated in LUAD compared to normal lung tissue, it is currently unknown whether ZNF768 expression associates with clinicopathological features in LUAD. Here, using tissue microarrays o

SUBMITTER: Poirier A 

PROVIDER: S-EPMC8391643 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature