GRP78 Overexpression Triggers PINK1-IP3R-Mediated Neuroprotective Mitophagy.

ABSTRACT: An experimental model of spinal root avulsion (RA) is useful to study causal molecular programs that drive retrograde neurodegeneration after neuron-target disconnection. This neurodegenerative process shares common characteristics with neuronal disease-related processes such as the presence of endoplasmic reticulum (ER) stress and autophagy flux blockage. We previously found that the overexpression of GRP78 promoted motoneuronal neuroprotection after RA. After that, we aimed to unravel the underlying mechanism by carrying out a comparative unbiased proteomic analysis and pharmacological and genetic interventions. Unexpectedly, mitochondrial factors turned out to be most altered when GRP78 was overexpressed, and the abundance of engulfed mitochondria, a hallmark of mitophagy, was also obse

SUBMITTER: Leiva-Rodriguez T 

PROVIDER: S-EPMC8391647 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature