Enhanced Biomechanically Mediated "Phagocytosis" in Detached Tumor Cells.

ABSTRACT: Uptake of particles by cells involves various natural mechanisms that are essential for their biological functions. The same mechanisms are used in the engulfment of synthetic colloidal drug carriers, while the extent of the uptake affects the biological performance and selectivity. Thus far, little is known regarding the effect of external biomechanical stimuli on the capacity of the cells to uptake nano and micro carriers. This is relevant for anchorage-dependent cells that have detached from surfaces or for cells that travel in the body such as tumor cells, immune cells and various circulating stem cells. In this study, we hypothesize that cellular deformability is a crucial physical effector for the successful execution of the phagocytosis-like uptake in cancer cells. To test this assu

SUBMITTER: Goldstein Y 

PROVIDER: S-EPMC8391740 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature