Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction in the General Population.

ABSTRACT:

Importance

Olfactory dysfunction is a prodromal manifestation of many neurodegenerative disorders, including Alzheimer and Parkinson disease. However, its neuroanatomical basis is largely unknown.

Objective

To assess the association between olfactory brain structures and olfactory function in adults 30 years or older and to examine the extent to which olfactory bulb volume (OBV) mediates the association between central olfactory structures and olfactory function.

Design, setting, and participants

This cross-sectional study analyzed baseline data from the first 639 participants with brain magnetic resonance imaging (MRI) in the Rhineland Study, an ongoing population-based cohort study in Bonn, Germany. Participants were enrolled between March 7, 2016, and October 31, 2

SUBMITTER: Lu R 

PROVIDER: S-EPMC8391780 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature