Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling.

ABSTRACT: Background: The endothelial epsin 1 and 2 endocytic adaptor proteins play an important role in atherosclerosis by regulating the degradation of the calcium release channel inositol 1,4,5-trisphosphate receptor type 1 (IP3R1). In this study, we sought to identify additional targets responsible for epsin-mediated atherosclerotic endothelial cell activation and inflammation in vitro and in vivo. Methods: Atherosclerotic ApoE^-/- mice and ApoE^-/- mice with an endothelial cell-specific deletion of epsin 1 on a global epsin 2 knock-out background (EC-iDKO/ApoE^-/-), and aortic endothelial cells isolated from these mice, were used to examine inflammatory signaling in the endothelium. Results: Inflammatory signaling was significantly abrogated by

SUBMITTER: Dong Y 

PROVIDER: S-EPMC8391889 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature