Pseudogene Transcripts in Head and Neck Cancer: Literature Review and In Silico Analysis.

ABSTRACT: Once considered nonfunctional, pseudogene transcripts are now known to provide valuable information for cancer susceptibility, including head and neck cancer (HNC), a serious health problem worldwide, with about 50% unimproved overall survival over the last decades. The present review focuses on the role of pseudogene transcripts involved in HNC risk and prognosis. We combined current literature and in silico analyses from The Cancer Genome Atlas (TCGA) database to identify the most deregulated pseudogene transcripts in HNC and their genetic variations. We then built a co-expression network and performed gene ontology enrichment analysis to better understand the pseudogenes' interactions and pathways in HNC. In the literature, few pseudogenes have been studied in HNC. Our in silico analysi

SUBMITTER: Carron J 

PROVIDER: S-EPMC8391979 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature