Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome.

ABSTRACT:

Capsule

Hyperandrogenemia in an obese PCOS mouse model results in altered glucose/insulin metabolism and mitochondrial structure and function in the oocytes, in part explaining adverse outcomes and inheritance patterns seen in PCOS.

Objective

To study the oocyte quality by means of mitochondrial structure and function in a well-established classic PCOS mouse model.

Design

Animal study using an obese PCOS mouse model compared with control.

Setting

Animal research facility in a tertiary care university hospital setting.

Animals

C57/B6J mice.

Intervention

Three week old mice had subdermal implants of DHT controlled release pellet or placebo for 90 days.

Main outcome measures

The mouse model was validated by performing glucose tolerance test, H

SUBMITTER: Chappell NR 

PROVIDER: S-EPMC8392073 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature