Governing Heritable Human Genome Editing: A Textual History and a Proposal for the Future.

ABSTRACT: Heritable human genome editing (HHGE) has become a topic of intense public interest, especially since 2015. In the early 1980s, a related topic-human genetic engineering-was the subject of sustained public discussion. There was particular concern about germline genetic intervention. During the 1980s debate, an advisory committee to the Director of the National Institutes of Health (NIH)-the Recombinant DNA Advisory Committee (RAC)-agreed to provide initial public review of proposals for deliberate introduction of DNA into human beings. In 1984 and 1985, the RAC developed guidelines for research involving DNA transfer into patients. The committee also commented on the possibility of deliberately altering the human germline. We track the textual changes over time in the RAC's response to the

SUBMITTER: Walters L 

PROVIDER: S-EPMC8392078 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature