YAP-Dependent BiP Induction Is Involved in Nicotine-Mediated Oral Cancer Malignancy.

ABSTRACT: Cigarette smoking is a significant risk factor for the development and progression of oral cancer. Previous studies have reported an association between nicotine and malignancy in oral cancer. Recent studies have also demonstrated that nicotine can induce endoplasmic reticulum (ER) stress in tumor cells. Binding immunoglobulin protein (BiP) acts as a master regulator of ER stress and is frequently overexpressed in oral cancer cell lines and tissues. However, the effect of nicotine on BiP in oral cancer is unknown. Therefore, this study aimed to evaluate the role of BiP and its underlying regulatory mechanisms in nicotine-induced oral cancer progression. Our results showed that nicotine significantly induced the expression of BiP in time- and dose-dependent manners in oral squamous cell car

SUBMITTER: Chien CY 

PROVIDER: S-EPMC8392082 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature