The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network.

ABSTRACT: Altered connectivity within and between the resting-state networks (RSNs) brought about by anesthetics that induce altered consciousness remains incompletely understood. It is known that the dorsal attention network (DAN) and its anticorrelations with other RSNs have been implicated in consciousness. However, the role of DAN-related functional patterns in drug-induced sedative effects is less clear. In the current study, we investigated altered functional connectivity of the DAN during midazolam-induced light sedation. In a placebo-controlled and within-subjects experimental study, fourteen healthy volunteers received midazolam or saline with a 1-week interval. Resting-state fMRI data were acquired before and after intravenous drug administration. A multiple region of interest-driven analy

SUBMITTER: Wang J 

PROVIDER: S-EPMC8392174 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature