Pancreatic Progenitor Commitment Is Marked by an Increase in Ink4a/Arf Expression.

ABSTRACT: The identification of the molecular mechanisms controlling early cell fate decisions in mammals is of paramount importance as the ability to determine specific lineage differentiation represents a significant opportunity for new therapies. Pancreatic Progenitor Cells (PPCs) constitute a regenerative reserve essential for the maintenance and regeneration of the pancreas. Besides, PPCs represent an excellent model for understanding pathological pancreatic cellular remodeling. Given the lack of valid markers of early endoderm, the identification of new ones is of fundamental importance. Both products of the Ink4a/Arf locus, in addition to being critical cell-cycle regulators, appear to be involved in several disease pathologies. Moreover, the locus' expression is epigenetically

SUBMITTER: Montano E 

PROVIDER: S-EPMC8392192 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature