Heat Stress Reduces the Susceptibility of Caenorhabditis elegans to Orsay Virus Infection.

ABSTRACT: The nematode Caenorhabditis elegans has been a versatile model for understanding the molecular responses to abiotic stress and pathogens. In particular, the response to heat stress and virus infection has been studied in detail. The Orsay virus (OrV) is a natural virus of C. elegans and infection leads to intracellular infection and proteostatic stress, which activates the intracellular pathogen response (IPR). IPR related gene expression is regulated by the genes pals-22 and pals-25, which also control thermotolerance and immunity against other natural pathogens. So far, we have a limited understanding of the molecular responses upon the combined exposure to heat stress and virus infection. We test the hypothesis that the response of C. elegans to OrV in

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8392475 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature