Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1.

ABSTRACT: Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally. Family with sequence similarity 19 A1 (FAM19A1) is a secreted protein primarily expressed in subsets of terminally differentiated neuronal precursor cells and fully mature neurons in specific brain substructures. Several recent studies have demonstrated the importance of FAM19A1 in brain physiology; however, additional information is needed to support its role in neuronal maturation and function. In this study, dendritic spine morphology in Fam19a1-ablated mice and neurite development during in vitro neurogenesis were examined to understand the putative role of FAM19A1 in neural integrity. Adult Fam19a1-deficient mice showed low de

SUBMITTER: Yong HJ 

PROVIDER: S-EPMC8392516 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature