The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism.

ABSTRACT: Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to their biosynthesis. However, our understanding of their independent and co-regulation is limited. Cardiovascular disease is the leading cause of death globally and atherosclerosis, the pathology associated with elevated cholesterol, is the leading cause of cardiovascular disease. It is therefore important to understand vitamin D metabolism as a contributory factor. From the literature, we compile evidence of how these systems interact, relating the understanding of the molecular mechanisms involved to the results from observational studies. We also present the first systems biology pathway map of the joint cholesterol and vitamin D metabolisms made available using the Systems Biology Graphical Not

SUBMITTER: Warren T 

PROVIDER: S-EPMC8392689 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature