Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer's disease: A ¹H-[¹³C]-NMR study.

ABSTRACT: Alzheimer's disease (AD) is a very common neurodegenerative disorder. Although a majority of the AD cases are sporadic, most of the studies are conducted using transgenic models. Intracerebroventricular (ICV) administered streptozotocin (STZ) animals have been used to explore mechanisms in sporadic AD. In this study, we have investigated memory and neurometabolism of ICV-STZ-administered C57BL6/J mice. The neuronal and astroglial metabolic activity was measured in ¹H-[¹³C]-NMR spectrum of cortical and hippocampal tissue extracts of mice infused with [1,6-¹³C₂]glucose and [2-¹³C]acetate, respectively. STZ-administered mice exhibited reduced (p = 0.00002) recognition index for memory. The levels of creatine, GABA, glutamate and NAA were

SUBMITTER: Soni ND 

PROVIDER: S-EPMC8393290 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature