Crossed cerebellar diaschisis on ¹⁸F-FDG PET: Frequency across neurodegenerative syndromes and association with ¹¹C-PIB and ¹⁸F-Flortaucipir.

ABSTRACT: We used ¹⁸F-FDG-PET to investigate the frequency of crossed cerebellar diaschisis (CCD) in 197 patients with various syndromes associated with neurodegenerative diseases. In a subset of 117 patients, we studied relationships between CCD and cortical asymmetry of Alzheimer's pathology (β-amyloid (¹¹C-PIB) and tau (¹⁸F-Flortaucipir)). PET images were processed using MRIs to derive parametric SUVR images and define regions of interest. Indices of asymmetry were calculated in the cerebral cortex, basal ganglia and cerebellar cortex. Across all patients, cerebellar ¹⁸F-FDG asymmetry was associated with reverse asymmetry of ¹⁸F-FDG in the cerebral cortex (especially frontal and parietal areas) and basal ganglia. Based on our operational defi

SUBMITTER: Provost K 

PROVIDER: S-EPMC8393295 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature