Effects of mild hypoxia on oxygen extraction fraction responses to brain stimulation.

ABSTRACT: Characterizing the effect of limited oxygen availability on brain metabolism during brain activation is an essential step towards a better understanding of brain homeostasis and has obvious clinical implications. However, how the cerebral oxygen extraction fraction (OEF) depends on oxygen availability during brain activation remains unclear, which is mostly attributable to the scarcity and safety of measurement techniques. Recently, a magnetic resonance imaging (MRI) method that enables noninvasive and dynamic measurement of the OEF has been developed and confirmed to be applicable to functional MRI studies. Using this novel method, the present study investigated the motor-evoked OEF response in both normoxia (21% O₂) and hypoxia (12% O₂). Our results showed that OEF

SUBMITTER: Yin Y 

PROVIDER: S-EPMC8393298 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature