Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative.

ABSTRACT: Different species belonging to the genus Nephthea (Acyonaceae) are a rich resource for bioactive secondary metabolites. The literature reveals that the gastroprotective effects of marine secondary metabolites have not been comprehensively studied in vivo. Hence, the present investigation aimed to examine and determine the anti-ulcer activity of 4α,24-dimethyl-5α-cholest-8β,18-dihydroxy,22E-en-3β-ol (ST-1) isolated from samples of a Nephthea species. This in vivo study was supported by in silico molecular docking and protein-protein interaction techniques. Oral administration of ST-1 reduced rat stomach ulcers with a concurrent increase in gastric mucosa. Molecular docking calculations against the H⁺/K⁺-ATP

SUBMITTER: Mohamed TA 

PROVIDER: S-EPMC8393318 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature