Association between height-related polymorphism rs17081935 and reduced handgrip strength in relation to status of atherosclerosis: a cross-sectional study.

ABSTRACT:

Background

Aging is a process that increases oxidative stress. Increased oxidative stress leads to the development of atherosclerosis and mitochondrial dysfunction. Mitochondria contribute to energy production that might have a beneficial influence on maintaining muscle strength. Therefore, the height-related single nucleotide polymorphism (SNP) rs17081935, which is also reported to be associated with mitochondrial metabolism, might be associated with reduced muscle strength and this association might be affected by atherosclerosis status. To clarify those associations, a cross-sectional study of 1374 elderly Japanese individuals aged 60-89 years was conducted.

Methods

Logistic regression was used to clarify the association between rs17081935 and reduced handgrip strength. S

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC8393436 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature