Comparison of Quantification of Target-Specific Accumulation of [¹⁸F]F-siPSMA-14 in the HET-CAM Model and in Mice Using PET/MRI.

ABSTRACT: Assessment of biodistribution and specific tumor accumulation is essential for the development of new radiopharmaceuticals and requires animal experiments. The HET-CAM (hens-egg test-chorioallantoic membrane) model can be used in combination with the non-invasive imaging modalities PET and MRI for pre-selection during radiopharmaceutical development to reduce the number of animal experiments required. Critical to the acceptance of this model is the demonstration of the quantifiability and reproducibility of these data compared to the standard animal model. Tumor accumulation and biodistribution of the PSMA-specific radiotracer [¹⁸F]F-siPSMA-14 was analyzed in the chick embryo and in an immunodeficient mouse model. Evaluation was based on MRI and PET data in both models. γ-counte

SUBMITTER: Loffler J 

PROVIDER: S-EPMC8393674 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature