Set1 Targets Genes with Essential Identity and Tumor-Suppressing Functions in Planarian Stem Cells.

ABSTRACT: Tumor suppressor genes (TSGs) are essential for normal cellular function in multicellular organisms, but many TSGs and tumor-suppressing mechanisms remain unknown. Planarian flatworms exhibit particularly robust tumor suppression, yet the specific mechanisms underlying this trait remain unclear. Here, we analyze histone H3 lysine 4 trimethylation (H3K4me3) signal across the planarian genome to determine if the broad H3K4me3 chromatin signature that marks essential cell identity genes and TSGs in mammalian cells is conserved in this valuable model of in vivo stem cell function. We find that this signature is indeed conserved on the planarian genome and that the lysine methyltransferase Set1 is largely responsible for creating it at both cell identity and putative TSG loci. In addition, we s

SUBMITTER: Verma P 

PROVIDER: S-EPMC8393678 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature