A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants.
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ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC8393682 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants.
Feng Jing J Gao Yahui Y Wang Kun K Jiang Mingguo M
Genes 20210815 8
Recently, Zuotin-related factor 1 (ZRF1), an epigenetic regulator, was found to be involved in transcriptional regulation. In animals and humans, ZRF1 specifically binds to monoubiquitinated histone H2A through a ubiquitin-binding domain and derepresses Polycomb target genes at the beginning of cellular differentiation. In addition, ZRF1 can work as a tumor suppressor. According to bioinformatics analysis, ZRF1 homologs are widely found in plants. However, the current studies on ZRF1 in higher p ...[more]
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