The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy.

ABSTRACT: The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging. Due to the age-related decline in different anti-AGE mechanisms, including detoxifying mechanisms and proteolytic capacities, glycated biomolecules are accumulated during normal aging in our body in a tissue-dependent manner. Viewed in this way, anti-AGE detoxifying systems are proposed as therapeutic targets to fight pathological dysfunction associated with AGE accumulation and cytotoxicity. Here, we summarize the curren

SUBMITTER: Aragones G 

PROVIDER: S-EPMC8393707 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature