Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation.

ABSTRACT:

Background

Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects of antenatal sGCs have been reported, but their effects on placental epigenetic characteristics have never been systematically studied in humans.

Results

We tested the association between exposure to the sGC betamethasone (BET) and placental DNA methylation (DNAm) in 52 exposed cases and 84 gestational-age-matched controls. We fine-mapped associated loci using targeted bisulfite sequencing. The association of placental DNAm with gene expression and co-expression analysis on implicated genes was performed in an independent cohort including 494 placentas. Expos

SUBMITTER: Czamara D 

PROVIDER: S-EPMC8393766 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature