Prediction of Parkinson's Disease Risk Based on Genetic Profile and Established Risk Factors.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative disorder, and literature suggests that genetics and lifestyle/environmental factors may play a key role in the triggering of the disease. This study aimed to evaluate the predictive performance of a 12-Single Nucleotide Polymorphisms (SNPs) polygenic risk score (PRS) in combination with already established PD-environmental/lifestyle factors.

Methods

Genotypic and lifestyle/environmental data on 235 PD-patients and 464 controls were obtained from a previous study carried out in the Cypriot population. A PRS was calculated for each individual. Univariate logistic-regression analysis was used to assess the association of PRS and each risk factor with PD-status. Stepwise-regression analysis was used to select the best pr

SUBMITTER: Chairta PP 

PROVIDER: S-EPMC8393959 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature