Ontology highlight
ABSTRACT:
SUBMITTER: Le HP
PROVIDER: S-EPMC8394001 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Le Hang Phuong HP Heyer Wolf-Dietrich WD Liu Jie J
Genes 20210810 8
The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other cancers. Recent research advanced our mechanistic understanding of BRCA2 and its various interaction partners in DNA repair, DNA replication support, and DNA double-strand break repair pathway choice. In this review, we discuss the biochemical and structural properties of BRCA2 and examine how these fundamental properties contrib ...[more]