Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels.

ABSTRACT: Alginate hydrogels have been used as a biomaterial for 3D culturing for several years. Here, gene expression patterns in melanoma cells cultivated in 3D alginate are compared to 2D cultures. It is well-known that 2D cell culture is not resembling the complex in vivo situation well. However, the use of very intricate 3D models does not allow performing high-throughput screening and analysis is highly complex. 3D cell culture strategies in hydrogels will better mimic the in vivo situation while they maintain feasibility for large-scale analysis. As alginate is an easy-to-use material and due to its favorable properties, it is commonly applied as a bioink component in the growing field of cell encapsulation and biofabrication. Yet, only a little information about the transcriptome in 3D cultu

SUBMITTER: Kappelmann-Fenzl M 

PROVIDER: S-EPMC8394053 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature