Polymorphisms in HIF-1a gene are not associated with diabetic retinopathy in China.

ABSTRACT:

Background

It has been reported that vascular endothelial growth factor (VEGF) is a susceptibility gene for both type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR). In response to hypoxia, VEGF mRNA levels are increased, which is mainly mediated by the binding of hypoxia-inducible factor-1 (HIF-1) and hypoxia response element upstream of the transcriptional start site of VEGF. Therefore, HIF-1a is supposed to be involved in pathology of DR.

Aim

To investigate whether the polymorphisms in HIF-1a gene are associated with DR.

Methods

Two hundred and ninety-nine type 2 diabetic patients (128 males and 171 females) and 144 healthy volunteers were recruited. Mean age was 56.04 ± 21.05 years. According to the results of fundus fluorescein angiography and examinati

SUBMITTER: Liu YH 

PROVIDER: S-EPMC8394233 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature