HMP-S7 Is a Novel Anti-Leukemic Peptide Discovered from Human Milk.

ABSTRACT: Chemotherapy in childhood leukemia is associated with late morbidity in leukemic survivors, while certain patient subsets are relatively resistant to standard chemotherapy. It is therefore important to identify new agents with sensitivity and selectivity towards leukemic cells, while having less systemic toxicity. Peptide-based therapeutics has gained a great deal of attention during the last few years. Here, we used an integrative workflow combining mass spectrometric peptide library construction, in silico anticancer peptide screening, and in vitro leukemic cell studies to discover a novel anti-leukemic peptide having 3+ charges and an alpha helical structure, namely HMP-S7, from human breast milk. HMP-S7 showed cytotoxic activity against four distinct leukemic cell lines in a dose-depen

SUBMITTER: Chiangjong W 

PROVIDER: S-EPMC8394283 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature