Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World.

ABSTRACT: Diabetic retinopathy (DR) is a chronic complication of diabetes and a leading cause of blindness in the industrialized world. Traditional risk factors, such as glycemic control and duration of diabetes, are unable to explain why some individuals remain protected while others progress to a more severe form of the disease. Differences are also observed in DR heritability as well as the response to anti-vascular endothelial growth factor (VEGF) treatment. This review discusses various aspects of genetics in DR to shed light on DR pathogenesis and treatment. First, we discuss the global burden of DR followed by a discussion on disease pathogenesis as well as the role genetics plays in the prevalence and progression of DR. Subsequently, we provide a review of studies related to DR's genetic con

SUBMITTER: Bhatwadekar AD 

PROVIDER: S-EPMC8394456 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature