Dysregulation of Synaptic Signaling Genes Is Involved in Biology of Uterine Leiomyoma.

ABSTRACT: Uterine leiomyomas are tumors, which are hormone driven and originate from the smooth muscle layer of the uterine wall. In addition to known genes in leiomyoma pathogenesis, recent approaches also highlight epigenetic malfunctions as an important mechanism of gene dysregulation. RNA sequencing raw data from pair-matched normal myometrium and fibroid tumors from two independent studies were used as discovery and validation sets and reanalyzed. RNA extracted from normal myometrium and fibroid tumors from 58 Slovenian patients was used as independent confirmation of most significant differentially expressed genes. Subsequently, GWA data from leiomyoma patients were used in order to identify genetic variants at epigenetic marks. Gene Ontology analysis of the overlap of two independent RNA-seq

SUBMITTER: Krsteski J 

PROVIDER: S-EPMC8394462 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature