Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury.

ABSTRACT:

Background

Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammation may also promote iBRB restoration.

Methods

Using the mouse retinal ischemia-reperfusion (IR) injury model, we followed the time course of neurodegeneration, inflammation, and iBRB disruption and repair to examine the relationship between resolution of inflammation and iBRB restoration and to determine if minocycline, a tetracycline derivative shown to reverse microglial activation, can hasten these processes.

Results

A 90-min ischemic insult followed by reperfusion in the retina induced cell apoptosis and inner retina thinning that progressed for a

SUBMITTER: Abcouwer SF 

PROVIDER: S-EPMC8394696 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature