Antibody response to mRNA SARS-CoV-2 vaccines in haemodialysis patients.

ABSTRACT:

Background

Some studies have shown an attenuated immune response in haemodialysis patients after vaccination. The present study examines the humoral response after mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a large population of haemodialysis patients from different outpatient dialysis centres.

Methods

We retrospectively assessed antibodies against SARS-CoV-2 spike protein and nucleocapsid protein (chemiluminescence immunoassays, Roche diagnostics) 3-6 weeks after the second mRNA vaccine dose in 179 maintenance haemodialysis and 70 non-dialysis patients (control cohort). Differences in anti-SARS-CoV-2 spike protein titers were statistically analysed with respect to patient-relevant factors, including age, gender, previous coronav

SUBMITTER: Paal M 

PROVIDER: S-EPMC8394831 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature