Mitogen-Activated Protein Kinase Pathway in Amyotrophic Lateral Sclerosis.

ABSTRACT: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease. Multiple genetic and non-genetic risk factors are associated with disease pathogenesis, and several cellular processes, including protein homeostasis, RNA metabolism, vesicle transport, etc., are severely impaired in ALS conditions. Despite the heterogeneity of the disease manifestation and progression, ALS patients show protein aggregates in the motor cortex and spinal cord tissue, which is believed to be at least partially caused by aberrant phase separation and the formation of persistent stress granules. Consistent with this notion, many studies have implicated cellular stress, such as ER stress, DNA damage, oxidative stress, and growth factor depletion, in ALS conditions. The mitogen-activated protein kinase (

SUBMITTER: Sahana TG 

PROVIDER: S-EPMC8394856 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature