Hearing Function: Identification of New Candidate Genes Further Explaining the Complexity of This Sensory Ability.

ABSTRACT: To date, the knowledge of the genetic determinants behind the modulation of hearing ability is relatively limited. To investigate this trait, we performed Genome-Wide Association Study (GWAS) meta-analysis using genotype and audiometric data (hearing thresholds at 0.25, 0.5, 1, 2, 4, and 8 kHz, and pure-tone averages of thresholds at low, medium, and high frequencies) collected in nine cohorts from Europe, South-Eastern USA, Caucasus, and Central Asia, for an overall number of ~9000 subjects. Three hundred seventy-five genes across all nine analyses were tagged by single nucleotide polymorphisms (SNPs) reaching a suggestive p-value (p < 10^-5). Amongst these, 15 were successfully replicated using a gene-based approach in the independent Italian Salus in the Apulia c

SUBMITTER: Concas MP 

PROVIDER: S-EPMC8394865 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature