Spinal Cord Repair: From Cells and Tissue Engineering to Extracellular Vesicles.

ABSTRACT: Spinal cord injury (SCI) is a debilitating condition, often leading to severe motor, sensory, or autonomic nervous dysfunction. As the holy grail of regenerative medicine, promoting spinal cord tissue regeneration and functional recovery are the fundamental goals. Yet, effective regeneration of injured spinal cord tissues and promotion of functional recovery remain unmet clinical challenges, largely due to the complex pathophysiology of the condition. The transplantation of various cells, either alone or in combination with three-dimensional matrices, has been intensively investigated in preclinical SCI models and clinical trials, holding translational promise. More recently, a new paradigm shift has emerged from cell therapy towards extracellular vesicles as an exciting "cell-free" therap

SUBMITTER: Guo S 

PROVIDER: S-EPMC8394921 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature