Clinical Implication of Metformin in Relation to Diabetes Mellitus and Ovarian Cancer.

ABSTRACT: Since multiple reports established an association between diabetes mellitus and various cancers, emerging studies have surfaced to understand the effects of metformin as an anti-cancer agent. Although there was previous, but conflicting evidence, of a relationship between diabetes and ovarian cancer (OvCa), recent studies have supported this association. The mechanism of cancer development in patients with diabetes is likely to involve hyperglycemia, hyperinsulinemia, chronic inflammation, reactive oxygen species, regulation of cellular homeostasis, and activation of various pathways that lead to tumor cell proliferation. Preclinical evidence indicating that metformin, a medication commonly used to treat type 2 diabetes mellitus, may protect against OvCa. Metformin exerts anti-cancer prope

SUBMITTER: Singh SK 

PROVIDER: S-EPMC8394937 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature