Cell Therapy for Anal Sphincter Incontinence: Where Do We Stand?

ABSTRACT: Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life and induces high costs for the society. Surgery, considered as the best curative option, shows a disappointing success rate. Stem/progenitor cell therapy is pledging, for anal sphincter incontinence, a substitute to surgery with higher efficacy. However, the published literature is disparate. Our aim was to perform a review on the development of cell therapy for anal sphincter incontinence with critical analyses of its pitfalls. Animal models for anal sphincter incontinence were varied and tried to reproduce distinct clinical situations (acute injury or healed injury with or without surgical reconstruction) but were limited by anatomical considerations. Cell preparations used for treatment, origina

SUBMITTER: Balaphas A 

PROVIDER: S-EPMC8394955 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature