Tight Interplay between Replication Stress and Competence Induction in Streptococcus pneumoniae.

ABSTRACT: Cells respond to genome damage by inducing restorative programs, typified by the SOS response of Escherichia coli. Streptococcus pneumoniae (the pneumococcus), with no equivalent to the SOS system, induces the genetic program of competence in response to many types of stress, including genotoxic drugs. The pneumococcal competence regulon is controlled by the origin-proximal, auto-inducible comCDE operon. It was previously proposed that replication stress induces competence through continued initiation of replication in cells with arrested forks, thereby increasing the relative comCDE gene dosage and expression and accelerating the onset of competence. We have further investigated competence induction by genome stress. We find that absence of RecA recombinase stimulates competence induction

SUBMITTER: Khemici V 

PROVIDER: S-EPMC8394987 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature