Challenges and Opportunities of Targeting Astrocytes to Halt Neurodegenerative Disorders.

ABSTRACT: Neurodegenerative diseases are a heterogeneous group of disorders whose incidence is likely to duplicate in the next 30 years along with the progressive aging of the western population. Non-cell-specific therapeutics or therapeutics designed to tackle aberrant pathways within neurons failed to slow down or halt neurodegeneration. Yet, in the last few years, our knowledge of the importance of glial cells to maintain the central nervous system homeostasis in health conditions has increased exponentially, along with our awareness of their fundamental and multifaced role in pathological conditions. Among glial cells, astrocytes emerge as promising therapeutic targets in various neurodegenerative disorders. In this review, we present the latest evidence showing the astonishing level of speciali

SUBMITTER: Valori CF 

PROVIDER: S-EPMC8395029 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature