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Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators.

ABSTRACT: This review extensively reports data from the literature concerning the complex relationships between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton elements, which are actin filaments, microtubules, intermediate filaments, and septins. To a lesser extent, we also focused on the two membrane-associated cytoskeletons spectrin and ESCRT-III. We gather the mechanisms controlling cytoskeleton-associated JNK activation and the known cytoskeleton-related substrates directly phosphorylated by JNK. We also point out specific locations of the JNK upstream regulators at cytoskeletal components. We finally compile available techniques and tools that could allow a better characterization of the interplay between the different types of cytoskeleton filaments upon JNK-mediated stress and during development. This overview may bring new important information for applied medical research.

SUBMITTER: Benoit B

PROVIDER: S-EPMC8395060 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators.

Benoit Béatrice B Baillet Anita A Poüs Christian C

International journal of molecular sciences 20210804 16

This review extensively reports data from the literature concerning the complex relationships between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton elements, which are actin filaments, microtubules, intermediate filaments, and septins. To a lesser extent, we also focused on the two membrane-associated cytoskeletons spectrin and ESCRT-III. We gather the mechanisms controlling cytoskeleton-associated JNK activation and the known cytoskeleton-related substrates d ...[more]

PMID: 34445080

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