WNT Signaling as a Therapeutic Target for Glioblastoma.
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ABSTRACT:
SUBMITTER: Latour M
PROVIDER: S-EPMC8395085 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
WNT Signaling as a Therapeutic Target for Glioblastoma.
Latour Michael M Her Nam-Gu NG Kesari Santosh S Nurmemmedov Elmar E
International journal of molecular sciences 20210805 16
The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited. WNT has been recognized as a hallmark of therapeutic challenge due to its context-dependent role and critical function in healthy tissue homeostasis. In this review, we deeply scrutinize the WNT signaling pathway and its involvement in the genesis of glioblastoma as well as its acquired therapy resistance. We also provide a ...[more]
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