Roles of CCL2-CCR2 Axis in the Tumor Microenvironment.
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ABSTRACT:
SUBMITTER: Kadomoto S
PROVIDER: S-EPMC8395188 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Roles of CCL2-CCR2 Axis in the Tumor Microenvironment.
Kadomoto Suguru S Izumi Kouji K Mizokami Atsushi A
International journal of molecular sciences 20210808 16
Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of ...[more]
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