Ontology highlight
ABSTRACT:
SUBMITTER: Tylinska B
PROVIDER: S-EPMC8395211 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Tylińska Beata B Dobosz Agnieszka A Spychała Jan J Cwynar-Zając Łucja Ł Czyżnikowska Żaneta Ż Kuźniarski Amadeusz A Gębarowski Tomasz T
International journal of molecular sciences 20210806 16
Olivacine and ellipticine are model anticancer drugs acting as topoisomerase II inhibitors. Here, we present investigations performed on four olivacine derivatives in light of their antitumor activity. The aim of this study was to identify the best antitumor compound among the four tested olivacine derivatives. The study was performed using CCRF/CEM and MCF-7 cell lines. Comet assay, polarography, inhibition of topoisomerase II activity, histone acetylation, and molecular docking studies were pe ...[more]